![]() ![]() ResultsĬompared to SN and regardless of MJ use, the HIV+ group had lower FA and higher diffusivities in multiple white matter and subcortical structures ( p < 0.001–0.050), as well as poorer cognition in Fluency ( p = 0.039), Attention/Working Memory ( p = 0.009), Learning ( p = 0.014), and Memory ( p = 0.028). Using a 2 × 2 design, 44 HIV+ participants were compared to 46 seronegative participants on neuropsychological performance (7 cognitive domains) and diffusion tensor imaging metrics, using an automated atlas to assess fractional anisotropy (FA), axial (AD), radial (RD), and mean (MD) diffusivities, in 18 cortical and 4 subcortical brain regions. This study evaluated whether chronic marijuana (MJ) use contributes to additional cognitive deficits or brain microstructural abnormalities that may reflect neuroinflammation or neuronal injury in HIV+. ![]() Cognitive deficits and microstructural brain abnormalities are well documented in HIV-positive individuals (HIV+). ![]()
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